فولک ایسڈ: ہدایات ، اشارے ، درخواست کا طریقہ۔ ٹائمز ہب

فولک ایسڈ: ہدایات ، اشارے ، درخواست کا طریقہ۔ ٹائمز ہب


The drug is recommended to pregnant women, anemia and deficiency of folic acid

Фолиевая кислота: инструкция, показания, способ применения

After taking the drug, folic acid is to tetrahydrofolate, which functions as a coenzyme involved in various metabolic processes. It is required for normal maturation of megaloblasts and normoblasts education. Stimulates erythropoiesis, participates in the synthesis of amino acids (including methionine, serine, glycine and histidine), nucleic acids, purines, pyrimidines, involved in the metabolism of choline. Performs a protective function by teratogenic factors. In addition, contributes to the normal maturation and functioning of the placenta.

Folic acid plays an important role in the maturation of sperm and can be used for the treatment of male infertility.

When folic acid deficiency develops megaloblastic type of hematopoiesis in pregnant women it can cause fetal birth defects (neural tube defects, hydrocephalus). The most important consequence of folate deficiency is the decreased ability to repair damaged tissue.

The composition and form of issue

Active substance: folic acid.

Excipients: lactose, cellulose microcrystalline, starch maize, magnesium stearate.

Tablets are available in dosage of 0.4 mg, 1 mg or 5 mg of active substance by 30, 50 or 60 pieces in the package.

Basic physical and chemical properties: tablets of round shape with flat surface and beveled, light yellow color. Allowed heterogeneity of staining and minor blotches.

Pharmacotherapeutic group. Antianemic means. Folic acid and its derivatives. ATC code В03В В01.

How to get enough vitamins? Find in our story.


  • treatment and prevention of anemia related to folic acid deficiency: macrocytic anemia and leukopenia caused by drugs and ionizing radiation; megaloblastic anemia, post-resection anemia, sideroblastnoj anemia in elderly patients; anemia in inflammatory bowel diseases (Crohn’s disease, ulcerative colitis), malabsorption syndrome (celiac disease or celiac disease), sprue;
  • to prevent the development of fetal congenital defects: defects of the nerve trunk (hydrocephalus, brain herniation, “cleft palate”, “harelip”) in women planning pregnancy and are at risk;
  • long-term treatment with antagonists of folic acid (methotrexate, combination sulfamethoxazole-trimethoprim), anticonvulsants (phenytoin, primidon, phenobarbital)
  • folic acid deficiency is associated with an unbalanced or inadequate diet;
  • treatment of male infertility due to reduced spermatogenesis (oligospermia)
  • polyneuritis and polyneuropathy, including alcoholic etiology.


Hypersensitivity to folic acid or any component of medicine, vitamin B12 deficiency, malignancy, pernicious anemia, untreated cobalamin deficiency.


After intake of folic acid is well and completely absorbed from the digestive tract mainly in the upper duodenum and the proximal small intestine. Almost entirely associated with plasma proteins. About 87% of folate, which arrived in blood are erythrocytes, 10-13 % in the serum. Of blood folates originate in the liver, where they experience the activation by the enzyme dihydrofolate reductase, turning tetragidrofolievu acid. The maximum concentration in blood is reached in 30-60 minutes. Excreted by the kidneys mainly as metabolites; if the dose far exceeds the daily requirement of folic acid kidneys start to excrete the vitamin in an unmodified form. Excreted in the urine by glomerular filtration; 5 mg orally accepted folic acid excreted from the body after 5 hours. During hemodialysis is removed from the circulatory system.


Folic acid taken orally after a meal.

The dose and duration of treatment determines the physician depending on the nature and course of the disease.

For therapeutic purposes the drug should be administered to adults at 1-2 mg (1-2 tablets) 1-3 times a day. The maximum daily dose is 5 mg (5 tablets).

Children older than 3 years, depending on the child’s age and the nature of the disease, the drug must appoint 1 mg (1 tablet) 1-2 times a day. Maximum daily dose of 2 mg (2 tablets).

Usually the course of treatment is 20-30 days.

If the macrocytic anemia the drug must appoint adults: 5 mg 2-3 times a day for 10-15 days.

Pregnant women with a lower level of hemoglobin in the first trimester of pregnancy folic acid should be administered in a dose of 4 mg/day in combination with iron supplementation for 3 months. Then the dose of folic acid can reduce up to 4 mg 1 once a week.

Application features

The drug is administered with caution to patients with anemia of unknown etiology, because folic acid can interfere with the diagnosis of pernicious anemia by improving the hematologic manifestations of the disease while allowing progress to neurological complications.

This drug should not be used for healthy pregnant women, who can recommend the lowest dose, but need to be prescribed to pregnant women with folic acid deficiency or women who have a risk of recurrence of neural tube defects.

Long-term use of folic acid (especially at high doses) is not recommended due to possible reduction in blood levels of cyanocobalamin (vitamin B12).

In the treatment of folic acid requires systematic monitoring of blood.

In the elderly before starting long-term treatment is necessary to conduct the test on the absorption of cobalamin.

The drug contains glucose, which should be considered in patients with diabetes mellitus and patients with the syndrome of glucose-galactose malabsorption.

Folic acid is used in combination with other drugs: in pernicious anemia – only in combination with cyanocobalamin as folic acid, stimulating hematopoiesis, does not prevent the development of neurological complications (e.g. funicular myelosis); sprue – in combination with ascorbic acid, cyanocobalamin, with the conduct of gene therapy.

Use during pregnancy or breast-feeding. Folic acid deficiency, or metabolism of folic acid, is associated with the occurrence of birth defects and certain neural tube defects. Interference in the metabolism of folic acid or a folic acid deficiency as a result of action of certain drugs, e.g., anticonvulsants, anticancer drugs, early pregnancy leads to congenital anomalies. The lack of the vitamin or its metabolites can also influence the occurrence of spontaneous abortion and intrauterine growth retardation.

For therapeutic purposes the drug can be used by prescription in doses and duration specified in the instructions.

Children. Do not use medicines in children under the age of 3 years.

The ability to influence the reaction rate when driving motor transport or operating other mechanisms. With proper application of folic acid does not affect the ability to drive vehicles or work with mechanisms.

Side effects

  • From the digestive tract: nausea, vomiting, bloating, flatulence, bitter taste, anorexia.
  • The immune system: allergic reactions, including rashes, erythema, urticaria, pruritus and respiratory disorders as a result of bronchospasm, hypotension, anaphylactic reaction.
  • CNS: fever, upset night sleep, convulsions.
  • From the urinary system: hypertrophy of the epithelial cells in the tubules of the kidneys and the violation of their functions.


Patients with folate deficiency use of folic acid can reduce the level of phenobarbital, phenytoin and primidon in the blood plasma and cause epileptic seizures.

Oral contraceptives, ethanol, sulfasalazine, cycloserine, glutetimid and methotrexate can affect the metabolism of folate.

Acetylsalicylic acid may increase elimination of folic acid. Folates increase the efficiency of lithium. Nitrous oxide can cause acute folic acid deficiency.

Folic acid deficiency can cause such medicines as anti-TB drugs, folate antagonists such as pyrimethamine, triamterene, trimethoprim.

The absorption of folic acid decreases while the use of analgesics, anticonvulsants, antacids, chloramphenicol, neomycin, polimiksinami, antibiotics, sulfonamides, cytostatics.

Folic acid can reduce the absorption of zinc in the intestine.

Cannot be used together with mineral acids, alkaline substances, reducing agents due to inactivation of folic acid.

To avoid the simultaneous combination with fluorouracil. Antacids containing aluminum or magnesium may decrease the absorption of folic acid, therefore, patients should be advised to take antacids 2 hours after application of folic acid.

Folic acid enhances the metabolism of phenytoin. Reductions or shifts of absorption can occur with simultaneous use holestiramina and folic acid. Therefore, the drug should be taken 1 hour before or 4-6 hours after taking holestiramina.

Folic acid and alcohol. Drinking alcohol during treatment is not recommended, because in combination with folic acid this can lead to nausea, occurrence of vomiting reflexes, diseases of the stomach.


Overdose of folic acid can mask vitamin B12 deficiency.

Significant long-term abuse of the drug in the recommended doses can cause a dangerous accumulation of crystals Palatina, which leads to intoxication and increased side effects.

Treatment: cancel the drug, symptomatic therapy.

The expiration date. 3 years.

The storage conditions. At a temperature not exceeding 25 °C.

Category home away from home. Without a prescription.


  • Vitamins, PAO, Uman, Cherkasy region, Ukraine
  • Kyiv vitamin plant, PJSC, Kiev, Ukraine
  • Technologist CHAO, Uman, Cherkasy region, Ukraine

Price. From 105 to 220 UAH. Depending on the manufacturer.